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iTRAQ-based quantitative analysis of cancer-derived secretory proteome reveals TPM2 as a potential diagnosticbiomarker of colorectal cancer

Yiming Ma,Ting Xiao,Quan Xu,Xinxin Shao,Hongying Wang

Frontiers of Medicine 2016, Volume 10, Issue 3,   Pages 278-285 doi: 10.1007/s11684-016-0453-z

Abstract:

Colorectal cancer (CRC) is a leading cause of cancer-related deaths worldwide.for future biomarker applications and provided an efficient approach for the differential analysis of cancer-associated

Keywords： iTRAQ     secretome     colorectal cancer     TPM2    

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Growth suppression of colorectal cancer expressing S492R EGFR by monoclonal antibody CH12

Qiongna Dong, Bizhi Shi, Min Zhou, Huiping Gao, Xiaoying Luo, Zonghai Li, Hua Jiang

Frontiers of Medicine 2019, Volume 13, Issue 1,   Pages 83-93 doi: 10.1007/s11684-019-0682-z

Abstract:

Colorectal cancer (CRC) is a common malignant tumor in the digestive tract, and 30%–85% of CRCs express

Keywords： S492R EGFR ectodomain mutation     colorectal cancer     mAb CH12     immunnotherapy    

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Clinical Correlates and Prognostic Value of Different Metastatic Sites in Gastric and Colorectal Signet Article

Jingjing Wu, Daiqiong Fang, Da Man, Wenrui Wu, Qing Wang, Yating Li, Jianzhong Ye, Lanjuan Li

Engineering 2020, Volume 6, Issue 9,   Pages 1028-1034 doi: 10.1016/j.eng.2020.06.007

Abstract: its contribution to the cancer-specific survival of gastric SRCC and colorectal SRCC.with those without metastatic disease.In gastric SRCC, distant lymph nodes were the most common metastatic sites.In colorectal SRCC, the liver was the most common metastatic site, and patients with distant lymph nodeIn summary, metastasis is a major contributor to cancer mortality in SRCC.

Keywords： SEER Program     Survival analysis     Signet ring cell carcinoma     Metastases     Colorectal cancer     Gastric cancer    

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Neoadjuvant radiohormonal therapy for oligo-metastatic prostate cancer: safety and efficacy outcomes

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 231-239 doi: 10.1007/s11684-022-0939-9

Abstract: evaluate the safety and efficacy of neoadjuvant radiohormonal therapy for oligometastatic prostate cancerIn all, neoadjuvant radiohormonal therapy is well tolerated for oligometastatic prostate cancer.

Keywords： neoadjuvant     radiotherapy     oligometastatic     prostate cancer     radical prostatectomy    

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Altered intestinal microbiota associated with colorectal cancer

Hong Zhang, Ying Chang, Qingqing Zheng, Rong Zhang, Cheng Hu, Weiping Jia

Frontiers of Medicine 2019, Volume 13, Issue 4,   Pages 461-470 doi: 10.1007/s11684-019-0695-7

Abstract: The gut microbiota plays an important role in the development and progression of colorectal cancer (CRCdiffered between the groups, and the presence of specific bacteria may serve as a potential biomarker for colorectal

Keywords： colorectal cancer (CRC)     gut microbiota     intestinal     Eubacterium     Devosia    

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Chimeric antigen receptor T cell targeting EGFRvIII for metastatic lung cancer therapy

Zhao Zhang, Jun Jiang, Xiaodong Wu, Mengyao Zhang, Dan Luo, Renyu Zhang, Shiyou Li, Youwen He, Huijie Bian, Zhinan Chen

Frontiers of Medicine 2019, Volume 13, Issue 1,   Pages 57-68 doi: 10.1007/s11684-019-0683-y

Abstract:

Lung cancer is the most common incident cancer and the leading cause of cancer death.tumor-specific mutation expressed in various types of tumors and has been detected in non-small cell lung cancerThus, EGFRvIII is a potential antigen for targeted lung cancer therapy.EGFRvIII-CART showed significantly efficient antitumor activity against lung cancer cells expressingtargeting EGFRvIII is a potential therapeutic strategy in preventing recurrence and metastasis of lung cancer

Keywords： chimeric antigen receptor T cells     epidermal growth factor receptor     lung cancer     immunotherapy     tumor immunolog    

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Association of SIPA1 545 C>T polymorphism with survival in Chinese women with metastatic breast cancer

Renling Pei, Ye Xu, Yan Wei, Tao Ouyang, Jinfeng Li, Tianfeng Wang, Zhaoqing Fan, Tie Fan, Benyao Lin, Yuntao Xie

Frontiers of Medicine 2013, Volume 7, Issue 1,   Pages 138-142 doi: 10.1007/s11684-013-0247-5

Abstract: whether SIPA1 545 C>T polymorphism was associated with overall survival in patients with metastaticbreast cancer.In this study, SIPA1 545 C>T polymorphism was detected in 185 metastatic breast cancer patientsbreast cancer.Our findings indicate that metastatic breast cancer patients with SIPA1 545 T/T genotype have

Keywords： SIPA1     polymorphism     metastatic breast cancer     survival    

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The Composition of Colonic Commensal Bacteria According to Anatomical Localization in Colorectal Cancer

Liuyang Zhao, Xiang Zhang, Tao Zuo, Jun Yu

Engineering 2017, Volume 3, Issue 1,   Pages 90-97 doi: 10.1016/J.ENG.2017.01.012

Abstract:

Colorectal cancer (CRC) is a multistage disease resulting from complex factors, including geneticImbalance of the gut microbiota, especially dysregulated gut bacteria, contributes to colon cancer through

Keywords： Microbiota     Colorectal cancer     Luminal commensal bacteria     Translocation     Biomarker    

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Temporal Change in Treatment Patterns of Metastatic Colorectal Cancer and Its Association with Patient Article

Zi-Xian Wang, Yi-Chen Yao, Zong-Jiong Mai, Wu-Hao Lin, You-Sheng Huang, Ying Jin, Hui-Yan Luo, Dong-Sheng Zhang, Feng-Hua Wang, Feng Wang, Gong Chen, Pei-Rong Ding, Yun-Fei Yuan, Yu-Hong Li, Jin-Hua Huang, Zhi-Zhong Pan, Rui-Hua Xu

Engineering 2021, Volume 7, Issue 4,   Pages 526-533 doi: 10.1016/j.eng.2020.10.017

Abstract:

There is a lack of high-quality, large-scale, real-world evidence from patients with metastatic colorectalcancer (mCRC), especially in China.

Keywords： Metastatic colorectal cancer     Real-world evidence     Treatment pattern     Survival     Big-data platform    

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Profound Diversity of the N-Glycome from Microdissected Regions of Colorectal Cancer, Stroma Article

Di Wang, Katarina Madunić , Tao Zhang, Guinevere S.M. Lageveen-Kammeijer, Manfred Wuhrer

Engineering 2023, Volume 26, Issue 7,   Pages 32-43 doi: 10.1016/j.eng.2022.08.016

Abstract:

Aberrant glycosylation is considered to be a hallmark of colorectal cancer (CRC), as demonstratedWhile the N-glycosylation of cell lines and serum has been widely examined, the analysis of cancer-associatedtotal, 116 N-glycans were identified that showed profound differences in expression among cancerIn comparison with healthy mucosa, the cancer cells showed an increase in α2-6 sialylation andIn comparison with cancer, the stroma showed lower levels of oligomannosidic and monoantennary N<

Keywords： Colorectal cancer     Tumor     Porous graphitized carbon liquid chromatography mass spectrometry     N-glycomics    

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Neutron capture therapy clinical development in the world

Zhang Zichu,Jin Congjun,Liu Kai,Zhang Guozhen,Yang Lijun

Strategic Study of CAE 2012, Volume 14, Issue 8,   Pages 100-105

Abstract: treatment situation and evaluation in glioblastoma (GBM), malignant melanoma, recurrent head and neck cancerand metastatic liver cancer were discussed in detail.

Keywords： BNCT     GBM     malignant melanoma     recurent head & neck cancer     metastatic liver cancer    

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Genetic and Functional Differences of Escherichia coli Strains from Colorectal Cancer Mucosal Article

Yuxiao Chang, Xiang Li, Lei Ding, Chao Yang, Zhiyuan Pan, Ni Han, Yujun Cui, Fachao Zhi, Ruifu Yang, Hong Gao, Yujing Bi

Engineering 2022, Volume 16, Issue 9,   Pages 210-219 doi: 10.1016/j.eng.2021.03.028

Abstract:

Colorectal cancer (CRC) is the third leading cancer globally.

Keywords： Colorectal cancer     Gut microbiota     Culturomics     Escherichia coli     Strain level    

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Influence of Survivin-targeted siRNA on the biological features of colorectal carcinoma cells

XIONG Ying, GUO Wen, LI Ting, LI Ke

Frontiers of Medicine 2007, Volume 1, Issue 3,   Pages 304-307 doi: 10.1007/s11684-007-0058-7

Abstract: It provides a powerful evidence for colorectal carcinoma gene therapy.

Keywords： control     therapy     influence     Survivin-1     colorectal carcinoma    

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Establishment and drug sensitivity evaluation of murine ascites hepatocarcinoma cell line with high lymphatic metastatic

Hongying ZHANG, Jianwu TANG, Wenting ZHU, Chunxiu HU, Guowang XU

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 119-129 doi: 10.1007/s11684-009-0022-9

Abstract: effect of medicine against cells, a new murine ascites hepatocarcinoma cell line with high lymphatic metastaticMurine ascites hepatocarcinoma cell strain with low lymphatic metastatic potential (Hca-P) was subcutaneouslyinoculated into the medioventral line of a mouse 615 and the first generation of metastatic tumor cellsThe lymph node metastatic rate was 100%.

Keywords： murine ascites hepatocarcinoma cell line     metastasis     curcumin     drug sensitivity    

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treatment is associated with improved survival and increased response to immune checkpoint blockade in metastatic

Frontiers of Medicine   Pages 878-888 doi: 10.1007/s11684-023-0993-y

Abstract: A total of 182 patients with metastatic UM treated with immune checkpoint blockade (ICB) were includedPatients were recruited from prospective skin cancer centers and the German national skin cancer registryICB may be associated with a survival benefit and higher treatment response to ICB in patients with metastatic

Keywords： uveal melanoma     liver-directed therapy     immune checkpoint blockade     SIRT     anti-PD-1     anti-CTLA-4    

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Title Author Date Type Operation

iTRAQ-based quantitative analysis of cancer-derived secretory proteome reveals TPM2 as a potential diagnosticbiomarker of colorectal cancer

Yiming Ma,Ting Xiao,Quan Xu,Xinxin Shao,Hongying Wang

Journal Article

Growth suppression of colorectal cancer expressing S492R EGFR by monoclonal antibody CH12

Qiongna Dong, Bizhi Shi, Min Zhou, Huiping Gao, Xiaoying Luo, Zonghai Li, Hua Jiang

Journal Article

Clinical Correlates and Prognostic Value of Different Metastatic Sites in Gastric and Colorectal Signet

Jingjing Wu, Daiqiong Fang, Da Man, Wenrui Wu, Qing Wang, Yating Li, Jianzhong Ye, Lanjuan Li

Journal Article

Neoadjuvant radiohormonal therapy for oligo-metastatic prostate cancer: safety and efficacy outcomes

Journal Article

Altered intestinal microbiota associated with colorectal cancer

Hong Zhang, Ying Chang, Qingqing Zheng, Rong Zhang, Cheng Hu, Weiping Jia

Journal Article

Chimeric antigen receptor T cell targeting EGFRvIII for metastatic lung cancer therapy

Zhao Zhang, Jun Jiang, Xiaodong Wu, Mengyao Zhang, Dan Luo, Renyu Zhang, Shiyou Li, Youwen He, Huijie Bian, Zhinan Chen

Journal Article

Association of SIPA1 545 C>T polymorphism with survival in Chinese women with metastatic breast cancer

Renling Pei, Ye Xu, Yan Wei, Tao Ouyang, Jinfeng Li, Tianfeng Wang, Zhaoqing Fan, Tie Fan, Benyao Lin, Yuntao Xie

Journal Article

The Composition of Colonic Commensal Bacteria According to Anatomical Localization in Colorectal Cancer

Liuyang Zhao, Xiang Zhang, Tao Zuo, Jun Yu

Journal Article

Temporal Change in Treatment Patterns of Metastatic Colorectal Cancer and Its Association with Patient

Zi-Xian Wang, Yi-Chen Yao, Zong-Jiong Mai, Wu-Hao Lin, You-Sheng Huang, Ying Jin, Hui-Yan Luo, Dong-Sheng Zhang, Feng-Hua Wang, Feng Wang, Gong Chen, Pei-Rong Ding, Yun-Fei Yuan, Yu-Hong Li, Jin-Hua Huang, Zhi-Zhong Pan, Rui-Hua Xu

Journal Article

Profound Diversity of the N-Glycome from Microdissected Regions of Colorectal Cancer, Stroma

Di Wang, Katarina Madunić , Tao Zhang, Guinevere S.M. Lageveen-Kammeijer, Manfred Wuhrer

Journal Article

Neutron capture therapy clinical development in the world

Zhang Zichu,Jin Congjun,Liu Kai,Zhang Guozhen,Yang Lijun

Journal Article

Genetic and Functional Differences of Escherichia coli Strains from Colorectal Cancer Mucosal

Yuxiao Chang, Xiang Li, Lei Ding, Chao Yang, Zhiyuan Pan, Ni Han, Yujun Cui, Fachao Zhi, Ruifu Yang, Hong Gao, Yujing Bi

Journal Article

Influence of Survivin-targeted siRNA on the biological features of colorectal carcinoma cells

XIONG Ying, GUO Wen, LI Ting, LI Ke

Journal Article

Establishment and drug sensitivity evaluation of murine ascites hepatocarcinoma cell line with high lymphatic metastatic

Hongying ZHANG, Jianwu TANG, Wenting ZHU, Chunxiu HU, Guowang XU

Journal Article

treatment is associated with improved survival and increased response to immune checkpoint blockade in metastatic

Journal Article